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If you are unable to do this, then you will need to contact Actian Corporation via phone at 800-BTRIEVE or via Email at dbcic@actian.com. Be sure to have all of your critical information (version, product serial number, license key, etc.) available when you call, or provide all of the important details in your Email for fastest response. Better yet, click on the big red button to the left titled "Fix My PSQL License" and it'll take you right to Actian's web site, with a list of everything that they would ask you for.

If you are getting a Status 161 when you have a valid license installed, then you are most likely exceeding the number of allowable connected workstations. To confirm this, start the PSQL Monitor tool, select the Microkernel/Resource Usage menu item, and look at the Licenses line in the resulting dialog. Verify that the "Maximum" value matches the expected license count. (A mismatch could indicate a version problem.) Then, verify that the "Peak" is hitting the "Maximum" value. If so, then you have these options:

If you see a number of licenses that you cannot believe, then you can check into this further by going into the Microkernel/Active Users (or Active Sessions) screen. Click on the first user in the upper-left corner of the window, and write down the Network Address data found in the lower left quadrant. Press the down arrow to go to the next user session, and repeat this process for each database connection. If an address appears as a complete duplicate, you can skip it, because it has already been counted. You should get a number of unique network addresses that matches your current license count.

Chromosomal instability in cancer consists of dynamic changes to the number and structure of chromosomes1,2. The resulting diversity in somatic copy number alterations (SCNAs) may provide the variation necessary for tumour evolution1,3,4. Here we use multi-sample phasing and SCNA analysis of 1,421 samples from 394 tumours across 22 tumour types to show that continuous chromosomal instability results in pervasive SCNA heterogeneity. Parallel evolutionary events, which cause disruption in the same genes (such as BCL9, MCL1, ARNT (also known as HIF1B), TERT and MYC) within separate subclones, were present in 37% of tumours. Most recurrent losses probably occurred before whole-genome doubling, that was found as a clonal event in 49% of tumours. However, loss of heterozygosity at the human leukocyte antigen (HLA) locus and loss of chromosome 8p to a single haploid copy recurred at substantial subclonal frequencies, even in tumours with whole-genome doubling, indicating ongoing karyotype remodelling. Focal amplifications that affected chromosomes 1q21 (which encompasses BCL9, MCL1 and ARNT), 5p15.33 (TERT), 11q13.3 (CCND1), 19q12 (CCNE1) and 8q24.1 (MYC) were frequently subclonal yet appeared to be clonal within single samples. Analysis of an independent series of 1,024 metastatic samples revealed that 13 focal SCNAs were enriched in metastatic samples, including gains in chromosome 8q24.1 (encompassing MYC) in clear cell renal cell carcinoma and chromosome 11q13.3 (encompassing CCND1) in HER2+ breast cancer. Chromosomal instability may enable the continuous selection of SCNAs, which are established as ordered events that often occur in parallel, throughout tumour evolution.

Recognizing that accelerated global action is needed to address the pervasive and corrosive problem of the double burden of malnutrition, in 2012 the World Health Assembly Resolution 65.6 endorsed a Comprehensive implementation plan on maternal, infantand young child nutrition, which specified a set of six global nutrition targets that by 2025 aim to:

While the United States has 707 incarcerated people per 100,000 citizens, for example, China has 124 to 172 per 100,000 people and Iran 284 per 100,000. North Korea is perhaps the closest, but reliable numbers are hard to find; some estimates suggest 600 to 800 per 100,000. (See "Incarceration rates per 100,000" chart.)

Mental illness among today's inmates is also pervasive, with 64 percent of jail inmates, 54 percent of state prisoners and 45 percent of federal prisoners reporting mental health concerns, the report found. Substance abuse is also rampant and often co-occurring.

"Part of what's really swelled our jail and prison population, especially our jail population, is our inability to deal with the mental health crisis that we're facing in this country," says Tangney. "We have an enormous number of people who are suffering from very treatable illnesses who are not getting treatment and who end up getting caught in the criminal justice system as opposed to the mental health system."

Even within the United States, crime rates have varied while the incarceration rate has shot up. For example, the number of people in prison for drugs is 10 times higher today than it was 30 to 40 years ago, yet the amount of drug crime hasn't changed.

Costs for inmates to access medical and mental health care are another concern. Most prisoners enter prison as indigents; if they have Medicaid, Medicare, Social Security or similar resources, those are discontinued. Many federal prisons, a majority of state prisons and an unknown number of jails require prisoners to pay a co-pay of $2 to $5 for medical visits, in an attempt to reduce frivolous use of medical services (fees can be waived for emergencies). Prisoners generally pay for these services from the minimal wages they earn doing prison jobs, yet the cost of the visits can deter them from seeking preventive and routine care.

Some of these measures were recommended in the NRC report, which urges policymakers to revise criminal justice policies to reduce the rate of incarceration; to review mandatory minimums, long sentences and drug laws; and to consider more community-based alternatives to prison. But beyond steps to simply cut sentences and reduce the number of people in prison, the committee also recommends resources to help ensure prisoners are supported so they don't re-offend. For example, the committee recommended more vocational training and better prisoner re-entry programs as well as more research into the impact of mental illness and substance abuse on incarceration and recidivism. The committee also called for policymakers to address the wider social and economic conditions that cause crime in the first place, such as poverty, drug addiction and lack of education.

"The recommendations we made to reduce the number of people in prison and the amount of time they spent there need to go hand in hand with the other recommendations we made, which underscore the importance of providing people with resources while they're in prison to reduce the likelihood they'll come out unprepared to reintegrate into society," Haney says.

"We cannot tolerate pervasive and persistent misconduct at any bank and the consumers harmed by Wells Fargo expect that robust and comprehensive reforms will be put in place to make certain that the abuses do not occur again," Chair Janet L. Yellen said. "The enforcement action we are taking today will ensure that Wells Fargo will not expand until it is able to do so safely and with the protections needed to manage all of its risks and protect its customers."

Harassment remains a pervasive problem in American workplaces. The number of harassment charges filed with the EEOC and state fair employment practices agencies has risen significantly in recent years. For example, the number of sexual harassment charges has increased from 6,883 in fiscal year 1991 to 15,618 in fiscal year 1998. The number of racial harassment charges rose from 4,910 to 9,908 charges in the same time period.

If it is determined that the tangible action was based on a discriminatory reason linked to the preceding harassment, relief could be sought for the entire pattern of misconduct culminating in the tangible employment action, and no affirmative defense is available.40 However, the harassment preceding the tangible employment action must be severe or pervasive in order to be actionable.31 If the tangible employment action was based on a non-discriminatory motive, then the employer would have an opportunity to raise the affirmative defense to a claim based on the preceding harassment.42

The policy should encourage employees to report harassment before it becomes severe or pervasive. While isolated incidents of harassment generally do not violate federal law, a pattern of such incidents may be unlawful. Therefore, to discharge its duty of preventive care, the employer must make clear to employees that it will stop harassment before it rises to the level of a violation of federal law.

A determination as to whether an employee unreasonably failed to complain or otherwise avoid harm depends on the particular circumstances and information available to the employee at that time.84 An employee should not necessarily be expected to complain to management immediately after the first or second incident of relatively minor harassment. Workplaces need not become battlegrounds where every minor, unwelcome remark based on race, sex, or another protected category triggers a complaint and investigation. An employee might reasonably ignore a small number of incidents, hoping that the harassment will stop without resort to the complaint process.85 The employee may directly say to the harasser that s/he wants the misconduct to stop, and then wait to see if that is effective in ending the harassment before complaining to management. If the harassment persists, however, then further delay in complaining might be found unreasonable.

How big is diversified enough? Classical portfolio theory says that in public equities, reasonable diversification effects can be expected when one combines 20 to 30 stocks, while more detailed recent studies set this number at 40 to 70. Most VC funds are of similar size: Why would this not be a sufficient number?

Diversifying is also hard to execute operationally. Managing a portfolio of 100, let alone 500, investments takes significantly more effort than managing a portfolio of 20 investments. Manpower resource constraints in particular come to mind, as VC funds usually have a surprisingly small number of senior partners and dealmakers. (Most VC funds are structured as partnerships, with each partner expected to manage five to at most ten deals. Scaling a partnership above ten or so partners rapidly becomes complex.) 2b1af7f3a8

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